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Efficacy and tolerability of OROS methylphenidate in Korean children with Attention-Deficit/Hyperactivity Disorder

Title
Efficacy and tolerability of OROS methylphenidate in Korean children with Attention-Deficit/Hyperactivity Disorder
Authors
Lee S.I.Hong S.D.Kim S.-Y.Kim E.-J.Kim J.-H.Park M.-K.Park S.Park J.-H.Oh E.-Y.Lim T.-S.Cheong S.Cho I.H.Choi J.W.
Ewha Authors
김의정
SCOPUS Author ID
김의정scopus
Issue Date
2007
Journal Title
Progress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN
0278-5846JCR Link
Citation
vol. 31, no. 1, pp. 210 - 216
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
This study evaluated the efficacy and tolerability in the initiation treatment of Concerta® (OROS methylphenidate HCl) in Korean children with Attention-Deficit/Hyperactivity Disorder (AD/HD). One hundred and nineteen children with AD/HD were entered into a multi-center, open-label, four-week trial. The dosage of Concerta® was adjusted by the investigators based on symptoms and safety assessments performed on a weekly basis. The safety of the drug and its efficacy for attention, behavior, and cognitive function were assessed. The primary outcome measures for efficacy were the Parent and Teacher IOWA Conners Rating Scales, Peer Interaction Items, and the Clinical Global Impression Scale. Cognitive tests (Continuous Performance Test, Matched Familiar Figure Test, Verbal Fluency Test, and Trail Making Test) were included as the secondary outcome measures. In most participants, OROS methylphenidate was well tolerated. There were significant improvements in attention, behavior, and function as measured by parents, teachers, and investigators. The benefit of the initiation of OROS methylphenidate in children with AD/HD was shown on the cognitive tests as well. These data provide support for the benefit of the once-daily methylphenidate preparation, Concerta® in the treatment of Korean children with AD/HD. Children were initiated safely in this short-term trial, and its effectiveness was evident in the behavioral, as well as neuropsychological measurements. © 2006 Elsevier Inc. All rights reserved.
DOI
10.1016/j.pnpbp.2006.09.002
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의학전문대학원 > 의학과 > Journal papers
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