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Synthesis and characterization of biocompatible poly(organophosphazenes) aiming for local delivery of protein drugs

Title
Synthesis and characterization of biocompatible poly(organophosphazenes) aiming for local delivery of protein drugs
Authors
Seong J.-Y.Jun Y.J.Kim B.M.Park Y.M.Sohn Y.S.
Ewha Authors
손연수
SCOPUS Author ID
손연수scopus
Issue Date
2006
Journal Title
International Journal of Pharmaceutics
ISSN
0378-5173JCR Link
Citation
vol. 314, no. 1, pp. 90 - 96
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Biocompatible and thermosensitive poly(organophosphazenes) with a lower critical solution temperature (LCST) below body temperature have been designed with the aim for the local delivery of peptide and protein drugs. These polymers could be synthesized by introducing short chain tri- or tetraethylene glycol as a hydrophilic group and a dipeptide, GlyGluEt 2 as a hydrophobic group into the polyphosphazene backbone. The local tolerance tests using rabbits have shown that our polymers are biocompatible. Using the amphiphilic properties of these polymers, in vitro studies were performed for loading and releasing of a human growth hormone (hGH) as a model drug. The entrapment efficiency (%) of hGH by the polymer decreased as its polymer concentration increased, but exhibited high efficiency of more than 95% even at 20% hGH concentration in the polymer. The entrapped hGH has shown to be controlled releasing for 3-4 days. © 2006 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ijpharm.2006.02.009
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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