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A Spätzle-processing enzyme required for toll signaling activation in drosophila innate immunity

Title
A Spätzle-processing enzyme required for toll signaling activation in drosophila innate immunity
Authors
Jang I.-H.Chosa N.Kim S.-H.Nam H.-J.Lemaitre B.Ochiai M.Kambris Z.Brun S.Hashimoto C.Ashida M.Brey P.T.Lee W.-J.
Ewha Authors
이원재
Issue Date
2006
Journal Title
Developmental Cell
ISSN
1534-5807JCR Link
Citation
vol. 10, no. 1, pp. 45 - 55
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The Toll receptor was originally identified as an indispensable molecule for Drosophila embryonic development and subsequently as an essential component of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro-Spätzle protein to generate the Toll ligand during development, the identification of the protease responsible for pro-Spätzle processing during the immune response has remained elusive for a decade. Here, we report a protease, called Spätzle-processing enzyme (SPE), required for Toll-dependent antimicrobial response. Flies with reduced SPE expression show no noticeable pro-Spätzle processing and become highly susceptible to microbial infection. Furthermore, activated SPE can rescue ventral and lateral development in embryos lacking Easter, showing the functional homology between SPE and Easter. These results imply that a single ligand/receptor-mediated signaling event can be utilized for different biological processes, such as immunity and development, by recruiting similar ligand-processing proteases with distinct activation modes. © 2006 Elsevier Inc.
DOI
10.1016/j.devcel.2005.11.013
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일반대학원 > 바이오융합과학과 > Journal papers
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