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In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres

Title
In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres
Authors
You Y.Lee S.W.Youk J.H.Min B.-M.Lee S.J.Park W.H.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2005
Journal Title
Polymer Degradation and Stability
ISSN
0141-3910JCR Link
Citation
vol. 90, no. 3, pp. 441 - 448
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.polymdegradstab.2005.04.015
Appears in Collections:
약학대학 > 약학과 > Journal papers
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