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G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells

Title
G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells
Authors
Kyoung A.K.Yeong W.K.Seung U.K.Chae S.Young S.K.Hee S.K.Min K.C.Dong H.K.Jin W.H.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2005
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 28, no. 6, pp. 685 - 690
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
We recently reported that the ginseng saponin metabolite, compound K (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits the growth of U937 cells through caspase-dependent apoptosis pathway. In this study, we further characterized the effects of compound K on U937 cells and found that, in addition to apoptosis, compound K induced the arrest of the G1 phase. The compound K treated U937 cells showed increased p21 expression; an inhibitory protein of cyclin-cdk complex. The up-regulation of p21 was followed by the inactivation of cyclin D and the cdk4 protein, which act at the early G1 phase, and cyclin E, which acts at the late G1 phase. Furthermore, compound K induced the activation of JNK and the transcription factor AP-1, which is a downstream target of JNK. These findings suggest that the up-regulation of p21 and activation of JNK in the compound K treated cells contribute to the arrest of the G1 phase.
DOI
10.1007/BF02969359
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의학전문대학원 > 의학과 > Journal papers
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