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Uric acid, endothelial dysfunction and pre-eclampsia: Searching for a pathogenetic link

Title
Uric acid, endothelial dysfunction and pre-eclampsia: Searching for a pathogenetic link
Authors
Kang D.-H.Finch J.Nakagawa T.Karumanchi S.A.Kanellis J.Granger J.Johnson R.J.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2004
Journal Title
Journal of Hypertension
ISSN
0263-6352JCR Link
Citation
vol. 22, no. 2, pp. 229 - 235
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Pre-eclampsia is strongly associated with hyperuricemia, and in some studies the increase in serum uric acid has been found to correlate with both maternal and fetal morbidity. The hyperuricemia is believed to result primarily from the decreased renal excretion that occurs as a consequence of the pre-eclampsia, and as such is widely viewed as a marker for pre-eclampsia as opposed to having a role in the pathogenesis. Hypothesis: We present the hypothesis that hyperuricemia may also have a contributory role in the development of hypertension and renal disease in these patients, and we review recent experimental data that would support this hypothesis. Recommendation: We suggest that studies addressing the role of uric acid in pre-eclampsia may provide new insights into both the pathogenesis and treatment of this condition. © 2004 Lippincott Williams & Wilkins.
DOI
10.1097/00004872-200402000-00001
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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