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Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
- Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
- Park D.-J.; Choi B.-H.; Zhu S.-J.; Huh J.-Y.; Kim B.-Y.; Lee S.-H.
- Ewha Authors
- Issue Date
- Journal Title
- Journal of Cranio-Maxillofacial Surgery
- vol. 33, no. 1, pp. 50 - 54
- SCI; SCIE; SCOPUS
- Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone. © 2004 European Association for Cranio-Maxillofacial Surgery.
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- 의과대학 > 의학과 > Journal papers
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