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Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites

Title
Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites
Authors
Park D.-J.Choi B.-H.Zhu S.-J.Huh J.-Y.Kim B.-Y.Lee S.-H.
Ewha Authors
이승호
Issue Date
2005
Journal Title
Journal of Cranio-Maxillofacial Surgery
ISSN
1010-5182JCR Link
Citation
vol. 33, no. 1, pp. 50 - 54
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone. © 2004 European Association for Cranio-Maxillofacial Surgery.
DOI
10.1016/j.jcms.2004.05.011
Appears in Collections:
의과대학 > 의학과 > Journal papers
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