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Uric acid and preeclampsia

Title
Uric acid and preeclampsia
Authors
Lam C.Lim K.-H.Kang D.-H.Karumanchi S.A.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2005
Journal Title
Seminars in Nephrology
ISSN
0270-9295JCR Link
Citation
vol. 25, no. 1, pp. 56 - 60
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Increased uric acid level is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbidity and mortality. The cause of hyperuricemia and its specific role in the pathogenesis of preeclampsia, however, remain unclear. Although uric acid has been shown to roughly parallel the severity of the maternal syndrome, it has not been useful in predicting the development of preeclampsia. Nevertheless, there have been recent data supporting a pathogenic role potentially in the hypertension and endothelial cell dysfunction of preeclampsia. This article reviews our current understanding of hyperuricemia in the setting of preeclampsia, and highlights the hypothesis that hyperuricemia may contribute to vascular damage in preeclampsia. © 2005 Elsevier Inc. All rights reserved.
DOI
10.1016/j.semnephrol.2004.09.009
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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