Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2016-08-28T11:08:14Z | - |
dc.date.available | 2016-08-28T11:08:14Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-12689 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228774 | - |
dc.description.abstract | CDX2 is an intestine-specific tumor suppressor gene encoding homeodomain-containing transcription factor, which is involved in a variety of developmental, proliferating, and differentiating processes. Moreover, the expression of CDX2 is reduced in a subset of primary colorectal cancers. In contrast, cyclooxygenase-2 (COX-2) is often up-regulated in human colorectal cancers. However, the molecular relationship between CDX2 down-regulation and COX-2 up-regulation is unknown. Here we show that CDX2 down-regulates COX-2 promoter activity by interacting with NF-κB. The ectopic expression of CDX2 was found to suppress PMA-induced COX-2 promoter activity in a dose-dependent manner. In addition, the treatment of colorectal cancer cells with PMA resulted in significant reduction in the level of endogenous CDX2 and a significant increase in the level of endogenous COX-2, in a dose-dependent manner. Furthermore, CDX2 was found to co-immunoprecipitate with the p65 subunit of NF-κB and to inhibit p65-induced NF-κB minimal promoter activity in colon cancer cells. These results suggest that reduced CDX2 expression may be involved in colorectal carcinogenesis by enhancing NF-κB-mediated inflammatory genes such as COX-2. © 2004 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 315 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 93 | - |
dc.relation.lastpage | 99 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2004.01.020 | - |
dc.identifier.wosid | WOS:000188966400014 | - |
dc.identifier.scopusid | 2-s2.0-10744228075 | - |
dc.author.google | Kim S.-P. | - |
dc.author.google | Park J.-W. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Lim J.H. | - |
dc.author.google | Jang B.-C. | - |
dc.author.google | Jang I.-H. | - |
dc.author.google | Freund J.-N. | - |
dc.author.google | Suh S.-I. | - |
dc.author.google | Mun K.C. | - |
dc.author.google | Song D.-K. | - |
dc.author.google | Ha E.-M. | - |
dc.author.google | Lee W.-J. | - |
dc.author.google | Kwon T.K. | - |
dc.contributor.scopusid | 이원재(57171092600) | - |
dc.date.modifydate | 20211210153636 | - |