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Induction of intercellular adhesion molecule-1 by Fas ligation: Proinflammatory roles of Fas in human astroglioma cells
- Induction of intercellular adhesion molecule-1 by Fas ligation: Proinflammatory roles of Fas in human astroglioma cells
- Choi K.; Benveniste E.N.; Choi C.
- Ewha Authors
- Issue Date
- Journal Title
- Neuroscience Letters
- vol. 352, no. 1, pp. 21 - 24
- SCI; SCIE; SCOPUS
- FasL has been shown to induce angiogenesis in vivo, however, the mechanism remains to be determined. We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL. Intercellular adhesion molecule (ICAM)-1 is increased in various human tumors, and is thought to be involved in the processes of metastasis and angiogenesis. We demonstrate that Fas ligation induces ICAM-1 expression at the mRNA and protein levels in human astroglioma cells. Studies using Boc-D-Fmk, a pharmacological inhibitor, show that caspase activation is required for Fas-mediated ICAM-1 induction. To study the in vivo expression of Fas and ICAM-1, human low-grade astrogliomas and glioblastoma multiforme (GBM) samples were examined by ELISA for Fas and ICAM-1. Human GBM samples express higher levels of Fas compared to normal control brain, which correlates with increased ICAM-1 expression. These findings suggest that Fas ligation on human glioma cells leads to the induction of ICAM-1 expression, which involves caspase cascade signaling pathways. © 2003 Elsevier Ireland Ltd. All rights reserved.
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