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Effect of ventilation mode on gas exchange during partial liquid ventilation at different perfluorocarbon doses in surfactant-depleted lung

Title
Effect of ventilation mode on gas exchange during partial liquid ventilation at different perfluorocarbon doses in surfactant-depleted lung
Authors
Lim C.-M.Yang S.-H.Kang J.-L.Koh Y.
Ewha Authors
이지희
SCOPUS Author ID
이지희scopus
Issue Date
2001
Journal Title
Lung
ISSN
0341-2040JCR Link
Citation
vol. 179, no. 4, pp. 245 - 255
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although gas ventilation is an integral part of partial liquid ventilation (PLV), the role of ventilation mode during PLV is not established, especially at a varying perfluorocarbon dose. In 10 surfactant-depleted rabbits, PLV was performed at a low dose (10 ml/kg) and at a functional residual capacity (FRC) dose (30 ml/kg) of perfluorodecalin in pressure-control (PC) and volume-control (VC) modes in balanced sequence. In these four PLV trials, PC mode was adjusted to be identical to VC mode with regard to tidal volume and inspiratory-to-expiratory ratio. PaO2 during PLV in PC mode was higher than in VC mode at the Low dose (159 ± 93 mm Hg, 115 ± 75 mm Hg, respectively: p = 0.005) and at the FRC dose (228 ± 114 mm Hg, 164 ± 104 mm Hg, respectively: p = 0.002). PaCO2 during PLV in PC mode was lower than in VC mode at the Low dose (59 ± 18 mm Hg, 72 ± 20 mm Hg, respectively: p = 0.005), whereas PaCO2 at the FRC dose was not different between modes. Curves of inspiratory flow appeared least deformed with PLV in PC mode at the Low dose, whereas they were saw-tooth deformed with PLV in VC mode at both doses. Actual time for inspiratory gas flow during PLV was shorter in PC mode compared with VC mode at both doses. In conclusion, in surfactant-depleted rabbit, gas exchange during PLV was better with PC mode compared with VC mode, especially at a low perfluorocarbon dose. Given the same tidal volume, PC appeared to insufflate the perfluorocarbon-filled lung better than VC at both low and FRC doses of perfluorocarbon.
DOI
10.1007/s004080000065
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의과대학 > 의학과 > Journal papers
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