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Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

Title
Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum
Authors
Seo E.-K.Kim N.-C.Mi Q.Chai H.Wall M.E.Wani M.C.Navarro H.A.Burgess J.P.Graham J.G.Cabieses F.Tan G.T.Farnsworth N.R.Pezzuto J.M.Kinghorn A.D.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2001
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 64, no. 11, pp. 1483 - 1485
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
DOI
10.1021/np0103158
Appears in Collections:
약학대학 > 약학과 > Journal papers
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