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Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats

Title
Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats
Authors
Kim H.-C.Jhoo W.-K.Ko K.H.Kim W.-K.Bing G.Kwon M.-S.Shin E.-J.Suh J.-H.Lee Y.-G.Lee D.-W.
Ewha Authors
김원기
Issue Date
2000
Journal Title
Life Sciences
ISSN
0024-3205JCR Link
Citation
vol. 66, no. 4, pp. 317 - 326
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We examined the effects of cigarette smoke (CS) on three parameters associated with kainic acid (KA)-induced neurotoxicity: seizure activity, cell loss in the hippocampus, and increased Fos-related antigen (FRA) expression. Animals were exposed to the main stream of CS from 15 Kentucky 2R1F research cigarettes containing 28.6 mg tar and 1.74 mg nicotine per cigarette, for 10 min a day, 6 days per week, for 4 weeks, using an automatic smoking machine. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4-5 h. Pre-exposure to CS significantly reduced the seizures, mortality, and severe loss of cells in regions CA1 and CA3 of the hippocampus after KA administration. Consistently, pre-exposure to CS significantly attenuated the KA-induced increased FRA immunoreactivity in the hippocampus. In contrast, pre-treatment with central nicotinic antagonist, mecamylamine (2 or 10 mg/kg, i.p.) blocked the neuroprotective effects mediated by CS in a dose-dependent manner. These results indicate that CS exposure provides neuroprotection against the KA insult via nicotinic receptor activation.
DOI
10.1016/S0024-3205(99)00593-7
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자연과학대학 > 화학·나노과학전공 > Journal papers
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