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Cytotoxic effects of quinoxaline derivatives on human cancer cell lines

Title
Cytotoxic effects of quinoxaline derivatives on human cancer cell lines
Authors
Yoo H.-W.Lee Y.-S.Suh M.E.Kim D.J.Park S.W.
Ewha Authors
서명은
SCOPUS Author ID
서명은scopus
Issue Date
1998
Journal Title
Archiv der Pharmazie
ISSN
0365-6233JCR Link
Citation
vol. 331, no. 10, pp. 331 - 333
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 compared with adriamycin and cis- platin used as anticancer drugs. The IC50 value of compound 10 was 0.073 μM while those of adriamycin and cis-platin were 0.12 μM and 2.67 μM, respectively.
DOI
10.1002/(SICI)1521-4184(199810)331:10&lt331::AID-ARDP331&gt3.0.CO2-I
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약학대학 > 약학과 > Journal papers
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