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Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer

Title
Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer
Authors
Jin E.H.Lee D.H.Jung S.-A.Shim K.-N.Seo J.Y.Kim N.Shin C.M.Yoon H.Jung H.C.
Ewha Authors
정성애심기남
SCOPUS Author ID
정성애scopus; 심기남scopus
Issue Date
2015
Journal Title
World Journal of Gastroenterology
ISSN
1007-9327JCR Link
Citation
vol. 21, no. 2, pp. 571 - 577
Keywords
CarcinomaEpidermal growth factorLymph nodeNeoplasm metastasisReceptorStomach neoplasms
Publisher
Baishideng Publishing Group Co., Limited
Indexed
SCIE; SCOPUS WOS scopus
Abstract
AIM: To analyze predictive factors for lymph node metastasis in early gastric cancer. METHODS: We analyzed 1104 patients with early gastric cancer (EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mutL homolog 1, p53, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic parameters. RESULTS: Lymph node metastasis was observed in 104 (9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients (3.8%) were mucosal cancers and 80 patients (16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4 (1.7%) for well differentiated tubular adenocarcinoma, 45 (11.3%) for moderately differentiated tubular adenocarcinoma, 36 (14.8%) for poorly differentiated tubular adenocarcinoma, and 19 (8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases (11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases (27.1%) of 406 EGC patients. With multivariate analysis, female gender (OR = 2.281, P = 0.009), presence of lymphovascular invasion (OR = 10.950, P < 0.0001), diameter (≥ 20 mm, OR = 3.173, P = 0.01), and EGFR overexpression (OR = 2.185, P = 0.044) were independent risk factors for lymph node involvement. CONCLUSION: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC. © 2015 Baishideng Publishing Group Inc. All rights reserved.
DOI
10.3748/wjg.v21.i2.563
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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