View : 183 Download: 0
Contralateral kidney volume change as a consequence of ipsilateral parenchymal atrophy promotes overall renal function recovery after partial nephrectomy
- Contralateral kidney volume change as a consequence of ipsilateral parenchymal atrophy promotes overall renal function recovery after partial nephrectomy
- Choi K.H.; Yoon Y.E.; Kim K.H.; Han W.K.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- International Urology and Nephrology
- International Urology and Nephrology vol. 47, no. 1, pp. 25 - 32
- Atrophy; Computed tomography; Glomerular filtration rate; Hypertrophy; Nephrectomy; Volumetric
- Kluwer Academic Publishers
- SCIE; SCOPUS
- Document Type
- Purpose: To evaluate whether ischemic time is related to ipsilateral parenchymal atrophy (IPA) and contralateral compensational hypertrophy (CCH) and how CCH affects late functional outcome after partial nephrectomy.Methods: Parenchymal kidney volumes and glomerular filtration rate (GFR) were determined preoperatively and at 3, 6, and 12 months postoperatively in 79 patients. Kidney volume was measured by Voxel Plus® 2.5 with a tissue segmentation tool. Correlation analysis and univariate and multivariate regression models were used to evaluate the recovery of IPA, CCH, and GFR.Results: The mean preserved ipsilateral kidney volume was 86.7 %. At 12 months, mean IPA and CCH were 3.0 and 4.8 %, respectively, and the mean GFR decrease was 8.0 %. Ipsilateral volume decrease and contralateral volume increase were significant until 6 months postoperatively (p < 0.05, for each). IPA and CCH were greater with a longer ischemic time (>35 min; p = 0.029 and 0.003, respectively), and CCH correlated positively with IPA (r2 = 0.052, p = 0.045). On multivariate analysis, IPA correlated with a longer ischemic time and percent of preserved normal parenchymal volume (PPV), and CCH correlated with a longer ischemic time, IPA, PPV, and total parenchymal volume increase. At 12 months postoperatively, CCH correlated with GFR recovery (r2 = 0.072, p = 0.026), and significant predictors of GFR recovery were age, sex, PPV, and CCH.Conclusions: We present the meaningful possibility that longer ischemic time and less preservation of normal parenchyma cause greater parenchymal atrophy, thereby promoting CCH, which contributes to renal function recovery after partial nephrectomy. © 2014, Springer Science+Business Media Dordrecht.
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.