Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽혜선 | * |
dc.contributor.author | 정호철 | * |
dc.date.accessioned | 2016-08-28T11:08:17Z | - |
dc.date.available | 2016-08-28T11:08:17Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1744-6872 | * |
dc.identifier.issn | 1744-6880 | * |
dc.identifier.other | OAK-12262 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228463 | - |
dc.description.abstract | A possible association between the combination of genetic variations in hepatocyte nuclear factor 4 (HNF4) and constitutive androstane receptor (CAR) and the stable doses of warfarin was examined in patients from the Ewha-Severance Treatment (EAST) Group of Warfarin. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; the vitamin K epoxide reductase complex 1 (VKORC1) genotype accounted for 29.6%, the cytochrome P450 (CYP) 2C9 genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4 (rs2501873/rs3212198) for 1.7%. Our results showed that the combination of CAR and HNF4 genotypes could be determinants of stable warfarin doses. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | * |
dc.language | English | * |
dc.publisher | LIPPINCOTT WILLIAMS & | * |
dc.publisher | WILKINS | * |
dc.subject | constitutive androstane receptor | * |
dc.subject | CYP2C9 | * |
dc.subject | hepatocyte nuclear factor 4 | * |
dc.subject | transcription factor | * |
dc.subject | warfarin | * |
dc.title | Combined effects of hepatocyte nuclear factor 4 alpha and constitutive androstane receptor on stable warfarin doses | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 38 | * |
dc.relation.lastpage | 40 | * |
dc.relation.journaltitle | PHARMACOGENETICS AND GENOMICS | * |
dc.identifier.doi | 10.1097/FPC.0000000000000103 | * |
dc.identifier.wosid | WOS:000346632900005 | * |
dc.identifier.scopusid | 2-s2.0-84918510873 | * |
dc.author.google | Moon, Jung Yeon | * |
dc.author.google | Lee, Kyung Eun | * |
dc.author.google | Chang, Byung Chul | * |
dc.author.google | Jeong, Eurim | * |
dc.author.google | Jeong, Hotcherl | * |
dc.author.google | Gwak, Hye Sun | * |
dc.contributor.scopusid | 정호철(55757505900) | * |
dc.date.modifydate | 20240422115307 | * |