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Selective zinc sensor based on pyrazoles and quinoline used to image cells

Title
Selective zinc sensor based on pyrazoles and quinoline used to image cells
Authors
Kim H.You G.R.Park G.J.Choi J.Y.Noh I.Kim Y.Kim S.-J.Kim C.Harrison R.G.
Ewha Authors
김성진김영미
SCOPUS Author ID
김성진scopus; 김영미scopus
Issue Date
2014
Journal Title
Dyes and Pigments
ISSN
0143-7208JCR Link
Citation
vol. 113, pp. 723 - 729
Keywords
Cell imagingFluorescenceQuinolineSelectiveVisible absorptionZinc sensor
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The synthesis, Zn2+ binding, crystal structure, and cell imaging studies of a new pyrazole amine quinoline receptor with a flexible binding pocket are described. Upon coordination to Zn2+, the absorption of the receptor increases at 364 nm and it fluoresces at 500 nm. The fluorescence response to Zn2+ is selective for Zn2+ and does not occur with other metal ions, not even Cd2+. In solution, the receptor forms 1:1 complexes with Zn2+, but in the solid-state two Zn2+ ions coordinate to the receptor. The aqueous solubility of the receptor allows for imaging of Zn2+ in living cells. Cells exposed to receptor and Zn2+ fluoresce when excited with visible light. © 2014 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.dyepig.2014.10.006
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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