Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T11:08:15Z | - |
dc.date.available | 2016-08-28T11:08:15Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 1612-1872 | * |
dc.identifier.other | OAK-12227 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228440 | - |
dc.description.abstract | Tuberostemonine stereoisomers are natural alkaloids found in Stemona tuberosa, that are known to have anti-inflammatory and anti-infective properties. Tuberostemonine alkaloids inhibit inflammation by suppressing the expression of inflammatory mediators such as cyclooxygenase and nitric oxide synthase. However, the direct immunomodulatory properties of tuberostemonine alkaloids in T cells have not been elucidated so far. In this study, the activities in T cells of tuberostemonine N (TbN) and a novel alkaloid, tuberostemonine O (TbO), isolated from S. tuberosa, were investigated. Although TbN did not have a significant effect on cytokine production in splenic T cells, TbO selectively suppressed interleukin (IL)-2 production. Moreover, TbO, but not TbN, significantly inhibited IL-2 production by primary CD4+ T cells and delayed the T-cell proliferation in a dose-dependent manner. Addition of excess recombinant IL-2 restored the decreased cell-division rates in TbO-treated CD4+ T cells to control levels. Collectively, these findings suggest that the immunomodulatory effects of TbO occurred by the suppression of IL-2 expression and IL-2-induced T-cell proliferation, suggesting a potential beneficial role of tuberostemonine alkaloids for the control of chronic inflammatory and autoimmune diseases caused by hyperactivated T cells. © 2014 Verlag Helvetica Chimica Acta AG. | * |
dc.language | English | * |
dc.publisher | Wiley-VCH Verlag | * |
dc.subject | Alkaloids | * |
dc.subject | CD4+ T cells | * |
dc.subject | Cell-division rates | * |
dc.subject | IL-2 production | * |
dc.subject | Immunomodulatory activity | * |
dc.subject | Stemona tuberosa | * |
dc.subject | Tuberostemonine alkaloids | * |
dc.title | Suppression of IL-2 production and proliferation of CD4+ T cells by tuberostemonine O | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1954 | * |
dc.relation.lastpage | 1962 | * |
dc.relation.journaltitle | Chemistry and Biodiversity | * |
dc.identifier.doi | 10.1002/cbdv.201400074 | * |
dc.identifier.wosid | WOS:000346096400008 | * |
dc.identifier.scopusid | 2-s2.0-84915820443 | * |
dc.author.google | Jang E.J. | * |
dc.author.google | Kil Y.-S. | * |
dc.author.google | Park H.R. | * |
dc.author.google | Oh S. | * |
dc.author.google | Kim H.K. | * |
dc.author.google | Jeong M.G. | * |
dc.author.google | Seo E.K. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |