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Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta

Title
Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta
Authors
Shin J.-A.Kim Y.-J.Park H.Kim H.-K.Lee H.-Y.
Ewha Authors
박혜숙이화영
SCOPUS Author ID
박혜숙scopus; 이화영scopus
Issue Date
2014
Journal Title
Gynecologic and Obstetric Investigation
ISSN
0378-7346JCR Link
Citation
vol. 78, no. 4, pp. 259 - 265
Keywords
Extravillous trophoblastFolateFolate metabolic enzymePregnancy-induced hypertensionSyncytiotrophoblast
Publisher
S. Karger AG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Normal fetal development requires adequate folate levels during pregnancy. Although folate metabolic enzymes have important roles in the maintenance of normal fetal development, the location of folate metabolic enzymes, methionine synthase (MTR) and 5,10-methylenetetrahydrofolate reductase (MTHFR), has not been previously examined. Methods: We investigated the expression of MTR and MTHFR in human term placenta obtained from normal and pregnancy-induced hypertension (PIH) patients. Results: MTR is expressed in the villous syncytiotrophoblast and MTHFR is expressed in the extravillous trophoblast. There was no difference in the quantity and location of these enzymes between control and PIH patients. Conclusion: These results suggest that MTR in the villous trophoblast participates in the metabolism of homocysteine by using folate, and MTHFR in the extravillous trophoblast is associated with extratrophoblast invasion. © 2014 S. Karger AG, Basel.
DOI
10.1159/000364866
Appears in Collections:
의과대학 > 의학과 > Journal papers
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