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Body mass index as a prognostic factor in organophosphate-poisoned patients

Title
Body mass index as a prognostic factor in organophosphate-poisoned patients
Authors
Lee, Duk HeeJung, Koo YoungChoi, Yoon HeeCheon, Young Jin
Ewha Authors
정구영전영진최윤희이덕희
SCOPUS Author ID
정구영scopus; 전영진scopus; 최윤희scopus
Issue Date
2014
Journal Title
AMERICAN JOURNAL OF EMERGENCY MEDICINE
ISSN
0735-6757JCR Link

1532-8171JCR Link
Citation
AMERICAN JOURNAL OF EMERGENCY MEDICINE vol. 32, no. 7, pp. 693 - 696
Publisher
W B SAUNDERS CO-ELSEVIER INC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Organophosphate poisoning is a serious clinical entity and considerable morbidity and mortality. Several factors have been identified to predict outcomes of organophosphate poisoning. Organophosphates are lipophilic and therefore predicted to have a large volume of distribution and to rapidly distribute into tissue and fat. Thus, toxic effects of organophosphate would be expected to last longer in obese patients. We investigated the relationship between obesity and clinical course in 112 acute organophosphate-poisoned patients from an initial medical record review of 234 patients. One hundred twenty-two patients were excluded: 6 were children, 14 had an uncertain history of exposure and of uncertain agent, 10 were transferred to another hospital, 67 were discharged from the emergency department because their toxicity was mild, 21 had carbamate poisoning, and 4 did not have height or weight checked. Clinical features, body mass index, Glasgow Coma Scale, laboratory findings, serum cholinesterase activity, electrocardiogram finding, management, and outcomes were examined. The lipid solubility of the implicated organophosphate was characterized by its octanol/water coefficient. Forty of 112 patients were obese. Obese patients who were poisoned by high lipophilicity organophosphate compounds had a need for longer use of mechanical ventilation, intensive care unit care, and total length of admission. Body mass index can provide a guide to physicians in predicting clinical course and management in organophosphate-poisoned patients. (C) 2014 Elsevier Inc. All rights reserved.
DOI
10.1016/j.ajem.2014.04.030
Appears in Collections:
의과대학 > 의학과 > Journal papers
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