View : 75 Download: 0

Genome-wide association study of ulcerative colitis in koreans suggests extensive overlapping of genetic susceptibility with caucasians

Genome-wide association study of ulcerative colitis in koreans suggests extensive overlapping of genetic susceptibility with caucasians
Yang S.-K.Hong M.Zhao W.Jung Y.Tayebi N.Ye B.D.Kim K.-J.Park S.H.Lee I.Shin H.D.Cheong H.S.Kim L.H.Kim H.J.Jung S.-A.Kang D.Youn H.-S.Liu J.Song K.
Ewha Authors
Issue Date
Journal Title
Inflammatory Bowel Diseases
1078-0998JCR Link
vol. 19, no. 5, pp. 954 - 966
Background: Recent genome-wide association studies and meta-analyses have identified 47 susceptibility loci for ulcerative colitis (UC) in Caucasian populations. A previous genome-wide association study of UC in a Japanese population suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. We performed a genome-wide association studies to identify UC susceptibility loci in a Korean population and further comparative study. Methods: We analyzed 581,060 autosomal single-nucleotide polymorphisms (SNPs) in 388 individuals with UC and 739 control subjects in the discovery stage. For the validation, 64 suggestive SNPs were analyzed in an additional 417 affected individuals and 732 control subjects. Results: Three genetic loci were validated for significant association, and all were previously reported in Caucasians including the major histocompatibility complex region (top SNP, rs9271366; P = 1.03 × 10-18, odds ratio [OR] = 2.10), 16q24.1 (rs16940186; P = 4.39 × 10-10, OR = 1.56), and RNF186-OTUD3-PLA2G2E at chromosome arm 1p36.13 (top SNP, rs4654903 in OTUD3; P = 7.43 × 10-9, OR = 0.64). Although failed to reach genome-wide statistical significance, 2 additional loci previously reported in Caucasians including rs17085007 at chromosome arm 13q12 and JAK2 at chromosome arm 9p24 were significant after Bonferroni correction (Pcorrected = 0.0016 and Pcorrected = 0.0056, respectively). FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC. Conclusions: Our data support the biologic significance of the overlapping loci for UC between Caucasian and Korean populations. Our data suggest that genetic associations for UC tend to overlap more extensively among different ethnic groups than those for Crohn's disease, which shows wellestablished dependence on ethnicity. Copyright © 2013 Crohn's & Colitis Foundation of America, Inc.
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.