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Effect of osmotic-release oral system methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder: An open-label study

Title
Effect of osmotic-release oral system methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder: An open-label study
Authors
Na K.-S.Lee S.I.Hong S.D.Kim J.-H.Shim S.-H.Choi J.Yang J.Lee M.-S.Joung Y.-S.Kim E.-J.Park J.-H.
Ewha Authors
김의정
SCOPUS Author ID
김의정scopus
Issue Date
2013
Journal Title
International Clinical Psychopharmacology
ISSN
0268-1315JCR Link
Citation
vol. 28, no. 4, pp. 184 - 192
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We evaluated the effect of osmotic-release oral system (OROS) methylphenidate on learning skills in adolescents with attention-deficit/ hyperactivity disorder (ADHD). In an open-label study, 121 adolescents with ADHD were administered flexible doses of OROS methylphenidate for 12 weeks. The efficacy of methylphenidate on ADHD symptoms was evaluated by ADHD Rating Scale (ARS) and Clinical Global Impression Scale (CGI). Learning Skills Test (LST) was used to measure the learning skills of the participants at the baseline and the endpoint. Continuous performance test, visuospatial and verbal working memory, verbal fluency, and inhibition were evaluated before and after the 12 weeks of treatment. The mean total and subscores of LST were significantly increased after the 12-week treatment with OROS methylphenidate. Executive functions were also improved during the trial, with the exception of inhibition measured by the Stroop Test. To the best of our knowledge, this is the first study to examine the influence of OROS methylphenidate on learning skill. As a result, OROS methylphenidate was effective in enhancing learning skills in adolescents with ADHD. © 2013 Wolters Kluwer Health

Lippincott Williams & Wilkins.
DOI
10.1097/YIC.0b013e3283612509
Appears in Collections:
의과대학 > 의학과 > Journal papers
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