View : 23 Download: 0

Posterior cerebellar vermal deficits in bipolar disorder

Title
Posterior cerebellar vermal deficits in bipolar disorder
Authors
Kim D.Cho H.B.Dager S.R.Yurgelun-Todd D.A.Yoon S.Lee J.H.Lee S.H.Lee S.Renshaw P.F.Lyoo I.K.
Ewha Authors
류인균이정현
SCOPUS Author ID
류인균scopus
Issue Date
2013
Journal Title
Journal of Affective Disorders
ISSN
0165-0327JCR Link
Citation
vol. 150, no. 2, pp. 499 - 506
Indexed
SCI; SCIE; SSCI; SCOPUS WOS scopus
Abstract
Background Based on growing evidence of the crucial role of the cerebellum in emotional regulation, we sought to identify cerebellar structural deficits in a large sample of patients with bipolar disorder (BD). Methods Cerebellar gray matter density was examined in 49 BD patients (24 medication-naive and 25 medication-treated) and 50 carefully matched healthy individuals, using voxel-based morphometry with a high-resolution spatially unbiased atlas template of the human cerebellum. This recently developed methodology is specifically optimized for the assessment of cerebellar structures. We further explored whether antimanic treatment could attenuate cerebellar structural deficits. Results BD patients showed a greater reduction in gray matter density of the posterior cerebellar regions, including the bilateral vermi and the right crus relative to healthy individuals (corrected p<.05). A stepwise linear reduction in gray matter density was observed in bilateral vermal regions between healthy individuals, medication-treated, and medication-naive BD patients. Furthermore, positive correlations of longer duration of illness with bilateral vermal gray matter deficits were observed only in medication-naive BD patients, but not in patients with medication history. Limitations This study adopted a cross-sectional design. The automatic intensity-normalization method for the measurement of cerebellar gray matter density may have a limitation in providing detailed anatomical information at a cerebellar folia level. Conclusions The current findings suggest that BD-related deficits in the posterior cerebellar regions, which appear to progress over the course of illness, could potentially be ameliorated by proper treatment with mood stabilizers. © 2013 Elsevier B.V.
DOI
10.1016/j.jad.2013.04.050
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE