Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons

Abstract

2 chloro 5 nitrobenzanilide; benzyloxycarbonylleucylleucylleucinal; cyclic AMP dependent protein kinase; cyclin dependent kinase 5; glycogen synthase kinase 3beta; lactacystin; peroxisome proliferator activated receptor gamma antagonist; phosphoprotein phosphatase 2A; protein p53; rosiglitazone; serine; tau protein; threonine; troglitazone; animal cell; article; brain cell; controlled study; dose response; down regulation; drug effect; drug inhibition; embryo; enzyme activity; female; gene repression; human; human cell; neuroblastoma cell; nonhuman; priority journal; protein cleavage; protein degradation; protein expression; protein phosphorylation; rat; signal transduction