Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-28T10:08:25Z | - |
dc.date.available | 2016-08-28T10:08:25Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-10396 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223988 | - |
dc.description.abstract | The exclusive distribution of 5-HT6 receptor in the brain regions and high affinity for antipsychotic and antidepressant drugs makes 5-HT6 receptor a promising target in treatment of CNS diseases. Based on a pharmacophore model reported in the literature, we designed and synthesized a novel series of 5-HT6 receptor ligands having indole as a central aromatic core and 1-amino-4-methyl piperazine as positive ionizable group. Out of 32 compounds we have successfully identified 10 new compounds as 5-HT6 receptor antagonists. The structure-activity relationship (SAR) studies have been carried out by mapping the compounds with the 3D QSAR model. © 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group | - |
dc.type | Article | - |
dc.relation.issue | 17 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 5573 | - |
dc.relation.lastpage | 5582 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2013.05.051 | - |
dc.identifier.wosid | WOS:000323294600075 | - |
dc.identifier.scopusid | 2-s2.0-84881376737 | - |
dc.author.google | Hayat F. | - |
dc.author.google | Cho S. | - |
dc.author.google | Rhim H. | - |
dc.author.google | Indu Viswanath A.N. | - |
dc.author.google | Pae A.N. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | Choo D.J. | - |
dc.author.google | Choo H.-Y.P. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |