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Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects

Title
Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects
Authors
Jeong H.S.Lee S.Yoon S.Jung J.J.Cho H.B.Kim B.N.Ma J.Ko E.Im J.J.Ban S.Renshaw P.F.Lyoo I.K.
Ewha Authors
류인균
SCOPUS Author ID
류인균scopus
Issue Date
2013
Journal Title
Drug and Alcohol Dependence
ISSN
0376-8716JCR Link
Citation
vol. 131, no. 3, pp. 222 - 229
Indexed
SCI; SCIE; SSCI; SCOPUS WOS scopus
Abstract
Background: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects. Methods: High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined. Results: Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus. Conclusions: Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity. © 2013 Elsevier Ireland Ltd.
DOI
10.1016/j.drugalcdep.2013.05.009
Appears in Collections:
약학대학 > 약학과 > Journal papers
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