Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.contributor.author | Pramod B. Shinde | * |
dc.date.accessioned | 2016-08-28T10:08:21Z | - |
dc.date.available | 2016-08-28T10:08:21Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1744-683X | * |
dc.identifier.other | OAK-10340 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223940 | - |
dc.description.abstract | Poly(ethylene glycol)-poly(alanine-co-phenylalanine) (PEG-PAF) block copolymers with similar molecular weights were synthesized to investigate the effect of the partial incorporation of d-alanine into PEG-l-PAF. The ratio of l-alanine to d-alanine of the polymer varied over 100/0, 80/20, 60/40, 50/50, and 0/100. Circular dichroism and FTIR spectra indicated that the PEG-PAFs with the mixed composition of l-alanine and d-alanine exhibited dominantly random coil structures, whereas the PEG-PAF with the enantiomeric alanine (100/0 or 0/100) exhibited right-handed or left-handed α-helical structures as well as β-sheet structures, respectively. Dynamic light scattering of the polymer aqueous solution indicated that the size of nanoassemblies significantly decreased as a result of the partial incorporation of d-alanine into PEG-l-PAF. The most probable diameters were 20-40 nm and 80-105 nm for the PEG-PAFs with a mixed composition (l-alanine/d-alanine ratios of 80/20, 60/40, and 50/50) and an enantiomeric composition (l-alanine/d-alanine ratios of 0/100 and 100/0), respectively. As the temperature increased, the relative β-sheet content decreased for PEG-PAF with the enantiomeric alanine, while there was no significant change in random coil structures of PEG-PAFs with a mixed composition. 13C-NMR spectra suggest the dehydration and decrease in molecular motion of PEG during the sol-to-gel transition of PEG-PAF. Through the partial incorporation of d-alanine into PEG-l-PAF, thermogelling behaviour was also observed at much higher temperatures and concentrations due to the difference in the secondary structure and nanoassembly of the polymers. The enzymatic degradability of PEG-PAF also decreased as a result of the partial incorporation of d-alanine into PEG-l-PAF. The paper suggests that partial incorporation of d-alanine into an l-polypeptide block copolymer can be a useful method in designing a biodegradable material as well as controlling nanoassemblies of the polymer. This journal is © The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.title | Incorporation of d-alanine into poly(ethylene glycol) and l-poly(alanine-co-phenylalanine) block copolymers affects their nanoassemblies and enzymatic degradation | * |
dc.type | Article | * |
dc.relation.issue | 33 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 8014 | * |
dc.relation.lastpage | 8022 | * |
dc.relation.journaltitle | Soft Matter | * |
dc.identifier.doi | 10.1039/c3sm51272j | * |
dc.identifier.wosid | WOS:000322544200019 | * |
dc.identifier.scopusid | 2-s2.0-84881191077 | * |
dc.author.google | Joo M.K. | * |
dc.author.google | Ko D.Y. | * |
dc.author.google | Jeong S.J. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Shinde U.P. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.contributor.scopusid | Pramod B. Shinde(8295253800) | * |
dc.date.modifydate | 20240118155902 | * |