Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2016-08-28T10:08:18Z | - |
dc.date.available | 2016-08-28T10:08:18Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2161-5063 | - |
dc.identifier.other | OAK-10314 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223917 | - |
dc.description.abstract | The polyketide synthase (PKS) biosynthetic code has recently expanded to include a newly recognized group of extender unit substrates derived from α,β-unsaturated acyl-CoA molecules that deliver diverse side chain chemistry to polyketide backbones. Herein we report the identification of a three-gene operon responsible for the biosynthesis of the PKS building block isobutyrylmalonyl-CoA associated with the macrolide ansalactam A from the marine bacterium Streptomyces sp. CNH189. Using a synthetic biology approach, we engineered the production of unnatural 36-methyl-FK506 in Streptomyces sp. KCTC 11604BP by incorporating the branched extender unit into FK506 biosynthesis in place of its natural C-21 allyl side chain, which has been shown to be critical for FK506's potent immunosuppressant and neurite outgrowth activities. © 2012 American Chemical Society. | - |
dc.language | English | - |
dc.title | Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 2 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 379 | - |
dc.relation.lastpage | 383 | - |
dc.relation.journaltitle | ACS Synthetic Biology | - |
dc.identifier.doi | 10.1021/sb3001062 | - |
dc.identifier.wosid | WOS:000322210200004 | - |
dc.identifier.scopusid | 2-s2.0-84880530282 | - |
dc.author.google | Lechner A. | - |
dc.author.google | Wilson M.C. | - |
dc.author.google | Ban Y.H. | - |
dc.author.google | Hwang J.-Y. | - |
dc.author.google | Yoon Y.J. | - |
dc.author.google | Moore B.S. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |