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Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: Effect of asymmetry on hemodynamics

Title
Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: Effect of asymmetry on hemodynamics
Authors
Marom G.Kim H.-S.Rosenfeld M.Raanani E.Haj-Ali R.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2013
Journal Title
Medical and Biological Engineering and Computing
ISSN
0140-0118JCR Link
Citation
vol. 51, no. 8, pp. 839 - 848
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97 % of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim of the present study was to characterize the effect of asymmetric BAV on the blood flow using fully coupled fluid-structure interaction (FSI) models with improved boundary conditions and tissue properties. This study presents four FSI models, including a native TAV, asymmetric BAVs with or without a raphe, and an almost symmetric BAV. Cusp tissue is composed of hyperelastic finite elements with collagen fibres embedded in the elastin matrix. A full cardiac cycle is simulated by imposing the same physiological blood pressures for all the TAV and BAV models. The latter have significantly smaller opening areas compared with the TAV. Larger stress values were found in the cusps of BAVs with fused cusps, at both the systolic and diastolic phases. The asymmetric geometry caused asymmetric vortices and much larger flow shear stress on the cusps which could be a potential initiator for early valvular calcification of BAVs. © 2013 International Federation for Medical and Biological Engineering.
DOI
10.1007/s11517-013-1055-4
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의학전문대학원 > 의학과 > Journal papers
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