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Leptin as a potential target for estrogen receptor-positive breast cancer

Title
Leptin as a potential target for estrogen receptor-positive breast cancer
Authors
Yom C.K.Lee K.-M.Han W.Kim S.-W.Kim H.S.Moon B.I.Jeong K.-Y.Im S.-A.Noh D.-Y.
Ewha Authors
문병인정구용
SCOPUS Author ID
문병인scopus; 정구용scopus
Issue Date
2013
Journal Title
Journal of Breast Cancer
ISSN
1738-6756JCR Link
Citation
vol. 16, no. 2, pp. 138 - 145
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: Leptin is a potent adipokine that plays a significant role in tumor development and the progression of breast cancer. The aim of this study was to evaluate whether leptin affects the response to tamoxifen treatment in estrogen receptor (ER)-positive breast cancer cells. Methods: Leptin, leptin receptor (Ob-R), and activation of signaling pathways were studied by Western immunoblotting. The effects of leptin on tamoxifen-dependent growth inhibition were studied in MCF-7 and T-47D cells. Results: Leptin was expressed in MCF-7 and T-47D and had a proliferative effect on MCF-7 cells. Leptin significantly inhibited the antiestrogenic effect of tamoxifen in both cells only under β-estradiol (E2) (20 nM) conditions. In MCF-7, the inhibitory effect against tamoxifen was a result from the activation of the ERK1/2 and STAT3 signal transduction pathway. Conclusion: Leptin interferes with the effects of tamoxifen under E2 stimulated conditions in ER-positive breast cancer cells. These results imply that inhibition of leptin is expected to enhance the response to tamoxifen in ER-positive breast cancer cells, and, therefore, could be a promising way to overcome endocrine resistance. © 2013 Korean Breast Cancer Society. All rights reserved.
DOI
10.4048/jbc.2013.16.2.138
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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