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Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings

Title
Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings
Authors
Bae C.-Y.Kang Y.G.Piao M.-H.Cho B.Cho K.H.Park Y.K.Yu B.Y.Lee S.-W.Kim M.J.Lee S.H.Kim Y.-J.Kim D.-H.Kim J.S.Oh J.E.
Ewha Authors
이상화
SCOPUS Author ID
이상화scopus
Issue Date
2013
Journal Title
Maturitas
ISSN
0378-5122JCR Link
Citation
vol. 75, no. 3, pp. 253 - 260
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives To date, no worldwide studies have been conducted to estimate the biological age of five organs using clinical biomarkers that are associated with the aging status. Therefore, we conducted this study to develop the models for estimating the biological age of five organs (heart, lung, liver, pancreas, and kidney) using clinical biomarkers which are commonly measured in clinical practice. Design A cross sectional study. Methods Subjects were recruited from the routine health check-up centers in Korea from 2004 through 2010. Data obtained from 121,189 subjects (66,168 men and 55,021 women) were used for clinical evaluation and statistical analysis. We examined the relations between clinical biomarkers associated with five organs and the chronological age and proposed a model for estimating the biological age of five organs. Results In the models for predicting the biological ages of the heart, lung, liver, pancreas and kidney in men, 12, 2, 8, 3, and 5 parameters were respectively included (R2 = 0.652, 0.427, 0.107, 0.245, and 0.651). In contrast to men, 10, 2, 8, 3, and 5 parameters in women were respectively included (R 2 = 0.780, 0.435, 0.140, 0.384, and 0.501). Conclusion We first proposed the models for predicting the biological age of five organs in the current study. We developed those using clinical parameters that can be easily obtained in clinical practice settings. Our biological age prediction models may be used as supplementary tools to assess the aging status of five organs in clinical practice settings. © 2013 Elsevier Ireland Ltd.
DOI
10.1016/j.maturitas.2013.04.008
Appears in Collections:
의과대학 > 의학과 > Journal papers
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