Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T10:08:10Z | - |
dc.date.available | 2016-08-28T10:08:10Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1019-6439 | * |
dc.identifier.other | OAK-10229 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223839 | - |
dc.description.abstract | Hypermethylation of runt-related transcription factor 3 (RUNX3) promoter regions occurs in at least 65% of colorectal cancer cell lines. Compound K, the main metabolite of ginseng saponin, induced demethylation of a RUNX3 promoter in HT-29 human colorectal cancer cells, assessed by methylation-specific PCR and the quantitative pyrosequencing analysis. The demethylation of RUNX3 in compound K-treated cells resulted in the re-expression of RUNX3 mRNA, protein and the localization into the nucleus. Demethylation of the RUNX3 gene by compound K occurred via inhibition of the expression and activity of DNA methyltransferase 1 (DNMT1). Compound K also significantly induced RUNX3-mediated expression of Smad4 and Bim. DNMT1 inhibitory activity by compound K was related to extracellular signal-regulated kinase (ERK) inhibition, assessed by siRNA transfection on DNMT1 and ERK. In conclusion, compound K significantly inhibits the growth of colorectal cancer cells by inhibiting DNMT1 and reactivating epigenetically-silenced genes. Ginseng saponin is a potential candidate as DNMT1 inhibitor in the chemoprevention of cancer. | * |
dc.language | English | * |
dc.title | The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 43 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 228 | * |
dc.relation.lastpage | 236 | * |
dc.relation.journaltitle | International Journal of Oncology | * |
dc.identifier.doi | 10.3892/ijo.2013.1931 | * |
dc.identifier.wosid | WOS:000321023100027 | * |
dc.identifier.scopusid | 2-s2.0-84879618317 | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |