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Identification of asthma clusters in two independent Korean adult asthma cohorts

Title
Identification of asthma clusters in two independent Korean adult asthma cohorts
Authors
Kim T.-B.Jang A.-S.Kwon H.-S.Park J.-S.Chang Y.-S.Cho S.-H.Choi B.W.Park J.-W.Nam D.-H.Yoon H.-J.Cho Y.-J.Moon H.-B.Cho Y.S.Park C.-S.
Ewha Authors
조영주
SCOPUS Author ID
조영주scopus
Issue Date
2013
Journal Title
European Respiratory Journal
ISSN
0903-1936JCR Link
Citation
vol. 41, no. 6, pp. 1308 - 1314
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Asthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management. We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA), and in 1843 subjects from another independent Korean asthma cohort of Soonchunhyang University Asthma Genome Research Centre (SCH) (Bucheon, Republic of Korea). Hierarchical cluster analysis was performed by Ward's method, followed by k-means cluster analysis. Cluster analysis of the COREA cohort indicated four asthma subtypes: 1) smoking asthma; 2) severe obstructive asthma; 3) early-onset atopic asthma; and 4) late-onset mild asthma. An independent cluster analysis of the SCH cohort also indicated four clusters that were similar to the COREA clusters. Our results indicate that adult Korean asthma patients can be classified into four distinct clusters. Copyright©ERS 2013.
DOI
10.1183/09031936.00100811
Appears in Collections:
의과대학 > 의학과 > Journal papers
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