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dc.contributor.author강상원*
dc.date.accessioned2016-08-28T10:08:05Z-
dc.date.available2016-08-28T10:08:05Z-
dc.date.issued2013*
dc.identifier.issn0165-5728*
dc.identifier.otherOAK-10155*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/223783-
dc.description.abstractReactive oxygen species (ROS) function as modulators of pro-inflammatory processes in microglia-associated neurodegenerative diseases.However, little is known about the involvement of specific antioxidants in regulating the microglial redox status. Here, we demonstrated that peroxiredoxin (Prx) I activity was induced by lipopolysaccharide (LPS), but not paraquat and hydrogen peroxide, through activation of the ROS/p38 MAPK signal pathway, and participated in alleviating the microglial activation and generation of nitric oxide (NO). Interestingly, a null mutation of Prx I accelerated NF-κB-mediated iNOS induction and subsequent NO secretion in LPS-stimulated microglia. Furthermore, F4/80 expression as microglial activation marker was notably up-regulated in primary cultures of microglia, hippocampal sections, and cerebral cortex of 15-month-old Prx I-/- mouse.Taken together, the results of our study indicated that Prx I is an antioxidant that is up-regulated in a ROS/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation. In addition, Prx I deficiency increased the nuclear translocation of NF-κB mediated-iNOS induction as pro-inflammatory mediators.The findings of our work suggest possible strategies for developing novel therapies to treat inflammation-associated degenerative neurological diseases by targeting the induction of Prx I in microglial cells. © 2013 Elsevier B.V.*
dc.languageEnglish*
dc.titlePeroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation*
dc.typeArticle*
dc.relation.issue41276*
dc.relation.volume259*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage26*
dc.relation.lastpage36*
dc.relation.journaltitleJournal of Neuroimmunology*
dc.identifier.doi10.1016/j.jneuroim.2013.03.006*
dc.identifier.wosidWOS:000319848100004*
dc.identifier.scopusid2-s2.0-84877596486*
dc.author.googleKim S.-U.*
dc.author.googlePark Y.-H.*
dc.author.googleMin J.-S.*
dc.author.googleSun H.-N.*
dc.author.googleHan Y.-H.*
dc.author.googleHua J.-M.*
dc.author.googleLee T.-H.*
dc.author.googleLee S.-R.*
dc.author.googleChang K.-T.*
dc.author.googleKang S.W.*
dc.author.googleKim J.-M.*
dc.author.googleYu D.-Y.*
dc.author.googleLee S.-H.*
dc.author.googleLee D.-S.*
dc.contributor.scopusid강상원(55731433900)*
dc.date.modifydate20240118155300*
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자연과학대학 > 생명과학전공 > Journal papers
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