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dc.contributor.author강상원-
dc.date.accessioned2016-08-28T10:08:05Z-
dc.date.available2016-08-28T10:08:05Z-
dc.date.issued2013-
dc.identifier.issn0165-5728-
dc.identifier.otherOAK-10155-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223783-
dc.description.abstractReactive oxygen species (ROS) function as modulators of pro-inflammatory processes in microglia-associated neurodegenerative diseases.However, little is known about the involvement of specific antioxidants in regulating the microglial redox status. Here, we demonstrated that peroxiredoxin (Prx) I activity was induced by lipopolysaccharide (LPS), but not paraquat and hydrogen peroxide, through activation of the ROS/p38 MAPK signal pathway, and participated in alleviating the microglial activation and generation of nitric oxide (NO). Interestingly, a null mutation of Prx I accelerated NF-κB-mediated iNOS induction and subsequent NO secretion in LPS-stimulated microglia. Furthermore, F4/80 expression as microglial activation marker was notably up-regulated in primary cultures of microglia, hippocampal sections, and cerebral cortex of 15-month-old Prx I-/- mouse.Taken together, the results of our study indicated that Prx I is an antioxidant that is up-regulated in a ROS/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation. In addition, Prx I deficiency increased the nuclear translocation of NF-κB mediated-iNOS induction as pro-inflammatory mediators.The findings of our work suggest possible strategies for developing novel therapies to treat inflammation-associated degenerative neurological diseases by targeting the induction of Prx I in microglial cells. © 2013 Elsevier B.V.-
dc.languageEnglish-
dc.titlePeroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation-
dc.typeArticle-
dc.relation.issue41276-
dc.relation.volume259-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage26-
dc.relation.lastpage36-
dc.relation.journaltitleJournal of Neuroimmunology-
dc.identifier.doi10.1016/j.jneuroim.2013.03.006-
dc.identifier.wosidWOS:000319848100004-
dc.identifier.scopusid2-s2.0-84877596486-
dc.author.googleKim S.-U.-
dc.author.googlePark Y.-H.-
dc.author.googleMin J.-S.-
dc.author.googleSun H.-N.-
dc.author.googleHan Y.-H.-
dc.author.googleHua J.-M.-
dc.author.googleLee T.-H.-
dc.author.googleLee S.-R.-
dc.author.googleChang K.-T.-
dc.author.googleKang S.W.-
dc.author.googleKim J.-M.-
dc.author.googleYu D.-Y.-
dc.author.googleLee S.-H.-
dc.author.googleLee D.-S.-
dc.contributor.scopusid강상원(55731433900)-
dc.date.modifydate20190901081003-
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