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Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay

Title
Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
Authors
Chang J.Lee A.Lee J.Lim W.Sung S.H.Moon B.-I.
Ewha Authors
성순희문병인임우성이안복
SCOPUS Author ID
성순희scopus; 문병인scopus; 임우성scopus
Issue Date
2013
Journal Title
Journal of the Korean Surgical Society
ISSN
1226-0053JCR Link
Citation
vol. 84, no. 6, pp. 313 - 320
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Purpose: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. Methods: Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. Results: In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. Conclusion: Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient. © Journal of the Korean Surgical Society 2013.
DOI
10.4174/jkss.2013.84.6.313
Appears in Collections:
의과대학 > 의학과 > Journal papers
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