View : 19 Download: 0

Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring

Title
Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring
Authors
Lee S.Lee K.A.Choi G.Y.Desai M.Lee S.H.Pang M.-G.Jo I.Kim Y.J.
Ewha Authors
김영주조인호
SCOPUS Author ID
김영주scopus; 조인호scopus
Issue Date
2013
Journal Title
Journal of Maternal-Fetal and Neonatal Medicine
ISSN
1476-7058JCR Link
Citation
vol. 26, no. 9, pp. 908 - 914
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. Study design: From 10d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. Results: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p<0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p<0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. Conclusion: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences. © 2013 Informa UK Ltd All rights reserved.
DOI
10.3109/14767058.2013.766686
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE