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Association of adiponectin gene polymorphism with birth weight in Korean neonates

Title
Association of adiponectin gene polymorphism with birth weight in Korean neonates
Authors
Kong K.A.Suh Y.J.Cho S.J.Park E.A.Park M.H.Kim Y.J.
Ewha Authors
박은애김영주박미혜조수진공경애
SCOPUS Author ID
박은애scopus; 김영주scopus; 박미혜scopus; 조수진scopus; 공경애scopusscopus
Issue Date
2013
Journal Title
Twin Research and Human Genetics
ISSN
1832-4274JCR Link
Citation
vol. 16, no. 3, pp. 732 - 738
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Adiponectin has been associated with insulin resistance and type 2 diabetes mellitus and possibly fetal growth. Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and the birth sizes. We investigated four SNPs of ADIPOQ (rs182052, rs2241766, rs1501299, and rs266729) and birth height and weight in 237 healthy full-term neonates. The neonates with the rs182052 G allele had a greater birth weight (p =.043 in the dominant model) and a higher ponderal index (p =.028 in the additive model). The rs2241766 G allele was associated with a greater birth weight (p =.016 in the recessive model). In a logistic regression analysis, the homozygotes for the rs182052 G allele and those for the rs2241766 G allele showed a significant association with a greater birth weight above 90 percentile (OR 2.75, 95% CI 1.13-6.70 and OR 5.15, 95% CI 1.66-15.99, respectively). In conclusion, we found an association between rs182052 and rs2241766 and birth weight and ponderal index among healthy neonates and suggested that adiponectin might have some roles in fetal growth. © 2013 The Authors.
DOI
10.1017/thg.2013.16
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의학전문대학원 > 의학과 > Journal papers
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