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Targeting syndecans: A promising strategy for the treatment of cancer

Title
Targeting syndecans: A promising strategy for the treatment of cancer
Authors
Choi S.Kang D.-H.Oh E.-S.
Ewha Authors
강덕희오억수
SCOPUS Author ID
강덕희scopus; 오억수scopus
Issue Date
2013
Journal Title
Expert Opinion on Therapeutic Targets
ISSN
1472-8222JCR Link
Citation
vol. 17, no. 6, pp. 695 - 705
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Introduction: Syndecans are cell surface adhesion receptors that play important functional roles. Their deregulation has been linked to several pathologies, and their aberrant regulation via diverse mechanisms is critically involved in the pathogenesis of various cancers. Similar to other receptors, syndecan functions are altered by ligand binding, overexpression, and extracellular domain shedding. These regulatory mechanisms may suggest new strategies for specifically controlling cancer cells. Areas covered: In this review, we describe the biological functions of syndecans in cancer, discuss their potential therapeutic relevance, and examine the current syndecan-targeting therapeutic options. Expert opinion: Since syndecans have diverse, specific, and novel regulatory functions in various cancers, therapeutic control of syndecan function has become an attractive approach for potential anticancer strategies. Syndecan and its associated proteins may also be strong candidate markers for the diagnosis and management of cancer, potentially opening a new era in cancer treatment. © 2013 Informa UK, Ltd.
DOI
10.1517/14728222.2013.773313
Appears in Collections:
의과대학 > 의학과 > Journal papers
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