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A case of IgM deficiency with b cell deficiency detected by abo discrepancy in a patient with acute osteomyelitis
- A case of IgM deficiency with b cell deficiency detected by abo discrepancy in a patient with acute osteomyelitis
- Jung C.L.; Cha M.-K.; Jun B.-H.; Hong K.-S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Annals of Laboratory Medicine
- vol. 33, no. 3, pp. 208 - 211
- SCIE; SCOPUS; KCI
- ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here, we describe a case of IgM deficiency discovered during the evaluation of an ABO discrepancy in a 16-yr-old Korean boy. ABO blood grouping showed that while his cell type was O+, serum typing detected only anti-A (3+). Anti-B was not detectable at room temperature but was graded at 1+ at 4°C. ABO genotyping revealed an O/O genotype. His serum IgG, IgA, and IgM concentrations were 770 mg/dL (reference range: 800-1,700 mg/dL), 244 mg/dL (reference range: 100-490 mg/dL), and 13.5 mg/dL (reference range: 50-320 mg/dL), respectively. He was diagnosed with acute osteomyelitis on the basis of clinical presentation and imaging studies. The symptoms gradually improved within 3 weeks of treatment. However, the ABO discrepancy and IgM deficiency persisted even 6 months after recovery and lymphocyte subset analysis revealed CD19+ B cell deficiency. To the best of our knowledge, IgM deficiency detected by ABO discrepancy in a patient with acute osteomyelitis has not been reported before. © The Korean Society for Laboratory Medicine.
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