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The role of uric acid in the pathogenesis of human cardiovascular disease

Title
The role of uric acid in the pathogenesis of human cardiovascular disease
Authors
Kanbay M.Segal M.Afsar B.Kang D.-H.Rodriguez-Iturbe B.Johnson R.J.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2013
Journal Title
Heart
ISSN
1355-6037JCR Link
Citation
vol. 99, no. 11, pp. 759 - 766
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
DOI
10.1136/heartjnl-2012-302535
Appears in Collections:
의과대학 > 의학과 > Journal papers
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