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Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037

Title
Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037
Authors
Wu Z.-C.Li S.Nam S.-J.Liu Z.Zhang C.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2013
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 76, no. 4, pp. 694 - 701
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Two new cyclic hexapeptides, nocardiamides A (1) and B (2), were isolated from the culture broth of marine-derived actinomycete CNX037 strain that was identified as a Nocardiopsis species. The planar structures of nocardiamides A (1) and B (2) were assigned on the basis of 1D and 2D NMR and HRESIMS spectroscopic analyses. Their absolute configurations were deduced by the advanced Marfey's method and chiral-phase HPLC analysis. The challenge of locating two d- and one l-valine residue in 1 and 2 was accomplished by total synthesis using solid-phase peptide synthetic methods. Both 1 and 2 showed negligible antimicrobial activities against seven indicator strains and exhibited no cytotoxicity against HCT-116. © 2013 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np400009a
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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