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Association between prenatal exposure to cadmium and atopic dermatitis in infancy

Title
Association between prenatal exposure to cadmium and atopic dermatitis in infancy
Authors
Kim J.H.Jeong K.S.Ha E.-H.Park H.Ha M.Hong Y.-C.Lee S.-J.Lee K.Y.Jeong J.Kim Y.
Ewha Authors
하은희박혜숙
SCOPUS Author ID
하은희scopus; 박혜숙scopus
Issue Date
2013
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 28, no. 4, pp. 516 - 521
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Our objective was to evaluate the relationship between intrauterine exposure to cadmium and the presence of atopic dermatitis in infants 6 months of age, adjusted for covariates including exposure to other heavy metals. The present research is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Study subjects were restricted to pregnant women in whom cadmium and lead levels were measured at delivery and whose infants were assessed for the presence of atopic disease at 6 months of age. The odds ratio (OR) for the presence of atopic dermatitis in 6-month-old infants whose cord blood had elevated cadmium levels, after adjustment for other covariates, was 2.350 (95% CI, 1.126-4.906). The OR for the presence of atopic dermatitis in infants whose cord blood had elevated lead levels was not significant. In the present study, the cord blood cadmium level was significantly associated with the presence of atopic dermatitis in 6-month-old infants; this was not true of the cord blood lead level. To the best of our knowledge, this is the first prospective study to show a relationship between prenatal exposure to cadmium and atopic dermatitis in infancy. © 2013 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2013.28.4.516
Appears in Collections:
의과대학 > 의학과 > Journal papers
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