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Comparative analysis between azacitidine and decitabine for the treatment of myelodysplastic syndromes

Title
Comparative analysis between azacitidine and decitabine for the treatment of myelodysplastic syndromes
Authors
Lee Y.-G.Kim I.Yoon S.-S.Park S.Cheong J.W.Min Y.H.Lee J.-O.Bang S.-M.Yi H.G.Kim C.S.Park Y.Kim B.-S.Mun Y.-C.Seong C.-M.Park J.Lee J.H.Kim S.-Y.Lee H.G.Kim Y.-K.Kim H.-J.
Ewha Authors
성주명문영철
SCOPUS Author ID
성주명scopus; 문영철scopus
Issue Date
2013
Journal Title
British Journal of Haematology
ISSN
0007-1048JCR Link
Citation
vol. 161, no. 3, pp. 339 - 347
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present study aimed to directly compare the efficacy and safety of azacitidine and decitabine in patients with myelodysplastic syndromes (MDS). We compared the overall response rate (ORR) (complete responses, partial responses, marrow complete responses, and haematological improvements), overall survival (OS), event-free survival (EFS), time to leukaemic transformation, and adverse outcomes between azacitidine and decitabine. To minimize the effects of treatment selection bias in this observational study, adjustments were made using the propensity-score matching method. Among 300 patients, 203 were treated with azacitidine and 97 with decitabine. Propensity-score matching yielded 97 patient pairs. In the propensity-matched cohort, there were no significant differences between the azacitidine and decitabine groups regarding ORR (44% vs. 52%), OS (26 vs. 22·9 months), EFS (7·7 vs. 7·0 months), and rate of leukaemic transformation (16% vs. 22% at 1 year). In patients ≥65 years of age, survival was significantly better in the azacitidine group (P = 0·017). Patients who received decitabine experienced more frequent episodes of grade 3 or 4 cytopenia and infectious episodes. We found that azacitidine and decitabine showed comparable efficacy. Among patients ≥65 years of age, survival was significantly better in the azacitidine group (ClinicalTrials.gov Identifier: NCT01409070). © 2013 Blackwell Publishing Ltd.
DOI
10.1111/bjh.12256
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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