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Animal models of cholangiocarcinoma

Title
Animal models of cholangiocarcinoma
Authors
Ko K.S.Peng J.Yang H.
Ewha Authors
고광석
SCOPUS Author ID
고광석scopus
Issue Date
2013
Journal Title
Current Opinion in Gastroenterology
ISSN
0267-1379JCR Link
Citation
vol. 29, no. 3, pp. 312 - 318
Indexed
SCIE; SCOPUS WOS scopus
Abstract
PURPOSE OF REVIEW: Even though recent accumulated data can help to understand fundamental molecular mechanisms of progression of cholangiocarcinoma (CCA), its incidence and mortality still keep increasing worldwide with poor prognosis. As appropriate animal disease models are critical to fill the gap between the findings from in vitro and the applications to human diseases, lack of effective and patient-like CCA animal models may contribute to limits of controlling progression of CCA. This review is focusing to provide the information about recently developed CCA animal models. RECENT FINDINGS: Recent advancements in cell and molecular biology make it possible to mimic the pathogenicity of human CCA using various animal models. In this review, several up-to-date techniques and the examples to induce CCA in animal models (xenograft and orthotopic models, carcinogen-induced CCA model, genetically engineered mouse model for CCA) with resemblance of human CCA are discussed. SUMMARY: Not only establishing animal models relevant to CCA is beneficial for its early diagnosis and therapy but also well suited experimental CCA models will guide the development of applicable treatment strategy for the hard-to-cure CCA. © 2013 Wolters Kluwer Health

Lippincott Williams &Wilkins.
DOI
10.1097/MOG.0b013e32835d6a3e
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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