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Cortico-cortical modulation induced by 1-Hz repetitive transcranial magnetic stimulation of the temporal cortex

Title
Cortico-cortical modulation induced by 1-Hz repetitive transcranial magnetic stimulation of the temporal cortex
Authors
Lee M.Kim S.E.Kim W.S.Han J.Kim H.J.Kim B.S.Kim J.Y.Hong S.B.Kim B.G.Lee H.W.
Ewha Authors
이향운김범산
SCOPUS Author ID
이향운scopus; 김범산scopus
Issue Date
2013
Journal Title
Journal of Clinical Neurology (Korea)
ISSN
1738-6586JCR Link
Citation
vol. 9, no. 2, pp. 75 - 82
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background and Purpose Repetitive transcranial magnetic stimulation (rTMS) has potential as a noninvasive neuromodulation treatment method for various neuropsychiatric disorders, and repeated sessions of rTMS are more likely to enhance the therapeutic efficacy. This study investigated neurophysiologic and spatiodynamic changes induced by repeated 1-Hz rTMS of the temporal cortex using transcranial magnetic stimulation (TMS) indices and fluorodeoxyglucose positron emission tomography (FDG-PET). Methods Twenty-seven healthy subjects underwent daily 1-Hz active or sham rTMS of the right temporal cortex for 5 consecutive days. TMS indices of motor cortical excitability were measured in both hemispheres daily before and after each rTMS session, and 2 weeks after the last stimulation. FDG-PET was performed at baseline and after the 5 days of rTMS sessions. Results All subjects tolerated all of the sessions well, with only three of them (11.1%) reporting mild transient side effects (i.e., headache, tinnitus, or local irritation). One-Hz rTMS decreased motor evoked potential amplitudes and delayed cortical silent periods in the stimulated hemisphere. Statistical parametric mapping of FDG-PET data revealed a focal reduction of glucose metabolism in the stimulated temporal area and an increase in the bilateral precentral, ipsilateral superior and middle frontal, prefrontal and cingulate gyri. Conclusions Repeated rTMS sessions for 5 consecutive days were tolerated in all subjects, with only occasional minor side effects. Focal 1-Hz rTMS of the temporal cortex induces cortico-cortical modulation with widespread functional changes in brain neural networks via long-range neural connections. © 2013 Korean Neurological Association.
DOI
10.3988/jcn.2013.9.2.75
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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