View : 22 Download: 0

Optimal hemoglobin A1C Cutoff Value for Diagnosing type 2 diabetes mellitus in Korean adults

Title
Optimal hemoglobin A1C Cutoff Value for Diagnosing type 2 diabetes mellitus in Korean adults
Authors
Lee H.Oh J.-Y.Sung Y.-A.Kim D.-J.Kim S.-H.Kim S.-G.Moon S.Park I.-B.Rhee E.-J.Chung C.-H.Kim B.-J.Ku B.-J.
Ewha Authors
성연아오지영이혜진
SCOPUS Author ID
성연아scopus; 오지영scopus; 이혜진scopus
Issue Date
2013
Journal Title
Diabetes Research and Clinical Practice
ISSN
0168-8227JCR Link
Citation
vol. 99, no. 2, pp. 231 - 236
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Commonly used tests for the diagnosis of diabetes include measurements of fasting plasma glucose levels and the oral glucose tolerance test (OGTT). Recently, a hemoglobin A1C (A1C) level of 6.5% has been included as a criterion for diabetes diagnosis by the American Diabetes Association. We aimed to determine appropriate A1C cutoff values for identifying patients with diabetes or prediabetes, including impaired glucose tolerance and impaired fasting glucose among Korean adults and to determine whether these cutoffs vary according to age. We recruited 4616 adults without a history of diabetes from 10 university hospitals. A 75-g OGTT and A1C sampling were performed in all examinees. Pointwise area under the receiver operating characteristic curve was used to evaluate the diagnostic accuracy of the A1C cutoff. An A1C threshold of 6.1% proved to be the optimal limit for diagnosing diabetes, with 63.8% sensitivity and 88.1% specificity. The cutoff value increased with age (5.9% in 18-39 years, 6.2% in 40-64 years, and 6.4% in older than 65 years) and were similar for men and women. An A1C cutoff of 5.7% had reasonable sensitivity (48.6%) and specificity (65.7%) for the identification of prediabetes. Further prospective studies should be carried out to determine whether the application of age-specific diagnostic criteria is appropriate. © 2012 Elsevier Ireland Ltd.
DOI
10.1016/j.diabres.2012.09.030
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE