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Activation of estrogen receptor β reduces blood-brain barrier breakdown following ischemic injury

Title
Activation of estrogen receptor β reduces blood-brain barrier breakdown following ischemic injury
Authors
Shin J.A.Yang S.J.Jeong S.I.Park H.J.Choi Y.-H.Park E.-M.
Ewha Authors
박은미최윤희
SCOPUS Author ID
박은미scopus; 최윤희scopus
Issue Date
2013
Journal Title
Neuroscience
ISSN
0306-4522JCR Link
Citation
vol. 235, pp. 165 - 173
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Estrogen receptors (ERs) play important roles in estrogen-mediated neuroprotection. However, their effects on blood-brain barrier (BBB) disruption with vasogenic edema after ischemic stroke have not been determined. We evaluated a role for ERβ in the brain without effects in the peripheral reproductive organs for the amelioration of vasogenic edema following ischemic stroke. Transient focal ischemic stroke was induced in ovariectomized female C57BL/6 mice (age 10-11. weeks) that were treated with the ERβ-selective agonist diarylpropionitrile (DPN). BBB breakdown as determined by the extravasation of endogenous immunoglobulin G (IgG), vasogenic edema, and the infarct volume was significantly reduced by DPN compared to vehicle. Protein expressions of endothelial tight junction proteins (occludin and claudin-5) and the water channel protein aquaporin 4 in the ischemic cortex were not changed by DPN. However, protein levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α), a transcription factor that increases VEGF expression, were significantly decreased in the ischemic cortex by DPN. These results suggest that ERβ contributes to the reduction of vasogenic edema caused by BBB breakdown via the inhibition of HIF-1α and VEGF following ischemic stroke. © 2013 IBRO.
DOI
10.1016/j.neuroscience.2013.01.031
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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