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Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: A multicenter, placebo-controlled, double-blind clinical study

Title
Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: A multicenter, placebo-controlled, double-blind clinical study
Authors
Choi Y.D.Park C.W.Jang J.Kim S.H.Jeon H.Y.Kim W.G.Lee S.J.Chung W.S.
Ewha Authors
정우식
SCOPUS Author ID
정우식scopus
Issue Date
2013
Journal Title
International Journal of Impotence Research
ISSN
0955-9930JCR Link
Citation
vol. 25, no. 2, pp. 45 - 50
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Ginseng is beneficial for many aspects of human physiology, including sexual function. In this study, we have evaluated the efficacy and safety of an extract of ginseng berry, which has a ginsenoside profile distinct from other parts of the plant, on sexual function in men with erectile dysfunction. In all, 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study. They were administered 4 tablets of either standardized Korean ginseng berry (SKGB, 350 mg ginseng berry extract per tablet), or placebo, daily, for 8 weeks. Efficacy was assessed with the International Index of Erectile Function (IIEF)-15 and premature ejaculation diagnostic tool (PEDT) at the end of the 4th and 8th week. We observed that the total and each of the individual domain scores of IIEF-15 increased from 40.95±7.05 to 46.19±12.69 significantly in the SKGB by the 8th week (P<0.05). The erectile function domain of IIEF changed slightly from 17.17±2.57 to 18.59±5.99 in the SKGB group by the 8th week (P<0.05). In addition, PEDT scores significantly improved from 9.14±4.57 to 7.97±4.4 and 7.53±4.26 in the SKGB group after 4 and 8 weeks of treatment (P<0.05). Safety markers including hormone and lipid in the blood were assessed at the end of the 4th and 8th week and they remained unchanged. Oral administration of the SKGB extract improved all domains of sexual function. It can be used as an alternative medicine to improve sexual life in men with sexual dysfunction. © 2012 Macmillan Publishers Limited All rights reserved.
DOI
10.1038/ijir.2012.45
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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