Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김용재 | - |
dc.date.accessioned | 2016-08-28T10:08:36Z | - |
dc.date.available | 2016-08-28T10:08:36Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.other | OAK-9865 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223526 | - |
dc.description.abstract | Background and purpose: Pre-existing brain infarct (PBI), frequently seen on magnetic resonance imaging and usually silent, is recognized as a risk factor for future stroke. Increased apolipoprotein B (apoB)/apoAI ratio is known to be a risk predictor of ischaemic stroke and is associated with intracranial atherosclerotic stenosis (ICAS). However, little is known about the association of apoB/apoAI ratio with PBI. Methods: A total of 522 statin-/fibrate-naïve Korean patients, who experienced acute ischaemic stroke, were categorized into three groups: ICAS (n = 254), extracranial (n = 51), and no cerebral atherosclerotic stenosis (n = 217). We explored the association between apoB/apoAI ratio and PBI lesions according to atherosclerosis type (ICAS, ECAS, and NCAS), PBI location (deep subcortical [ds-PBI] versus hemispheric [h-PBI]), and symptomatic PBI (s-PBI) which was relevant to a prior clinical stroke event. Results: Pre-existing brain infarct(+) patients showed a higher apoB/apoAI ratio than PBI(-) patients (0.81 ± 0.28 vs. 0.72 ± 0.23, P < 0.001). In ICAS group, patients with higher apoB/apoAI ratio quartiles had more PBIs, ds-PBIs, and s-PBIs (P = 0.020, P = 0.025, and P = 0.001, respectively). With multivariable analyses, the highest apoB/apoAI ratio quartile was associated with PBI (OR, 2.56; 95% CI, 1.39-4.73), ds-PBI (2.48; 1.33-4.62), and advanced (≥3) ds-PBIs (2.68; 1.27-5.63) in ICAS group, but not with h-PBI. s-PBI had a dose-response relationship with apoB/apoAI ratio quartiles (6.18; 1.31-29.13 for the second; 5.34; 1.06-26.83 for the third; and 12.17; 2.50-59.19 for the fourth quartile), when referenced to the first quartile. Conclusion: ApoB/apoAI ratio is associated with asymptomatic deep subcortical ischaemic burden as well as with symptomatic lesion in patients with ICAS. © 2012 The Author(s). European Journal of Neurology © 2012 EFNS. | - |
dc.language | English | - |
dc.title | Deep subcortical infarct burden in relation to apolipoprotein B/AI ratio in patients with intracranial atherosclerotic stenosis | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 20 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 671 | - |
dc.relation.lastpage | 680 | - |
dc.relation.journaltitle | European Journal of Neurology | - |
dc.identifier.doi | 10.1111/ene.12021 | - |
dc.identifier.wosid | WOS:000316258800018 | - |
dc.identifier.scopusid | 2-s2.0-84875036750 | - |
dc.author.google | Park J.-H. | - |
dc.author.google | Hong K.-S. | - |
dc.author.google | Lee J. | - |
dc.author.google | Kim Y.-J. | - |
dc.author.google | Song P. | - |
dc.contributor.scopusid | 김용재(36910759200) | - |
dc.date.modifydate | 20190301081000 | - |